A reader-funded review of treatments, supplements & cutting-edge wellness · Issue No. 14 · May 2026
Browse the full guide mapGLP-1s, tools, pipeline, sources
Research Library

Every review,
one place.

A clean article index with active, working links. Each piece includes its evidence label, review date, grade, and medical-advice disclaimer.

Retatrutide and “anti-aging” peptides: what the evidence can actually support.
Mixed / investigationalPeptides

Retatrutide and “anti-aging” peptides: what the evidence can actually support.

A source-backed review of a viral retatrutide, GHK-Cu, and MOTS-c video: where the biology is plausible, where human data exists, and where the claims outrun the evidence.

Orforglipron and the oral GLP-1 watchlist.
EmergingPipeline

Orforglipron and the oral GLP-1 watchlist.

Why a daily pill could change the GLP-1 market — and why convenience still does not answer efficacy, safety, access, and maintenance questions.

Amycretin, CagriSema, and the amylin moment.
EmergingPipeline

Amycretin, CagriSema, and the amylin moment.

The next metabolic medicine story may be less about one receptor and more about multi-pathway satiety signals.

The maintenance plan after GLP-1 weight loss.
Peer-reviewedGLP-1

The maintenance plan after GLP-1 weight loss.

Plateaus, protein, resistance training, coverage loss, dose changes, and the question everyone postpones: what happens if you stop?

The MASH-obesity crossover: mazdutide, pemvidutide, survodutide.
EmergingPipeline

The MASH-obesity crossover: mazdutide, pemvidutide, survodutide.

Why metabolic therapy is spilling into liver disease headlines, and how to avoid mixing up weight-loss, liver-fat, and MASH endpoints.

Tirzepatide, after the hype.
Peer-reviewedGLP-1

Tirzepatide, after the hype.

The uncomfortable parts of the GLP-1 boom that rarely make it into glossy before-and-afters: tolerance, muscle retention, cost, access, and what happens when treatment stops.

Semaglutide vs. Tirzepatide: a 36-week head-to-head.
Peer-reviewedGLP-1

Semaglutide vs. Tirzepatide: a 36-week head-to-head.

Mean BMI loss, lean-mass preservation, lipid panels and the side-effect curve nobody charts honestly.

Epitalon: the longevity peptide that won't quit the headlines.
EmergingPeptides

Epitalon: the longevity peptide that won't quit the headlines.

Old research, modern protocols, and why telomere language can sound more settled than the evidence actually is.

Polynucleotide salmon DNA injectables, audited.
Emerging clinicalAesthetic

Polynucleotide salmon DNA injectables, audited.

What early dermatology data and patient photos suggest: texture looks more plausible than lift, and the word “regenerative” needs a haircut.

The case for early HRT — and the studies that quietly buried the WHI.
Peer-reviewedHormones

The case for early HRT — and the studies that quietly buried the WHI.

Timing, symptom burden, bone density, risk stratification, and why menopause medicine still argues with a 2002 headline.

CJC-1295 / Ipamorelin: the growth-hormone stack, demystified.
EmergingRecovery

CJC-1295 / Ipamorelin: the growth-hormone stack, demystified.

Recovery claims, sleep anecdotes, glucose tradeoffs, and why the protocol matters more than the peptide-shop sales page.

Tretinoin at 0.025%, every other night, for ten years.
Peer-reviewedSkincare

Tretinoin at 0.025%, every other night, for ten years.

The boring skincare active that still beats most launches — if your barrier survives the onboarding period.